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08-Apr-2019 22:26

Sex specific incidence rate ratios estimated with log linear Poisson regression models adjusted for age, calendar period, education, and disposable income.

Results 358 403 subscription holders accrued 3.8 million person years.

Additional investigations showed that early male subscribers probably constituted a unique subgroup of people with a higher income and therefore a potentially distinct risk profile, particularly lower tobacco consumption.8We followed up the mobile phone subscriber study to 2007, with a focus on tumours of the central nervous system.

Longer follow-up increased the numbers of person years for subscribers, particularly in long term subscribers (≥10 years), in whom the total of person years under risk increased from 170 000 to 1.2 million.

There was no indication of dose-response relation either by years since first subscription for a mobile phone or by anatomical location of the tumour—that is, in regions of the brain closest to where the handset is usually held to the head.

Conclusions In this update of a large nationwide cohort study of mobile phone use, there were no increased risks of tumours of the central nervous system, providing little evidence for a causal association.

We had 3.21 million Danes for follow-up and the number of the mobile phone subscribers was reduced by 54 350 individuals compared with the previous design.

Disposable income was calculated from household income after taxation and the number of people in the household, deflated according to the 2000 value of the Danish Crown.

The CANULI cohort is therefore a nationwide cohort of all Danes aged 30 or older and born after 1925 in Denmark.

Because of the eligibility criteria of CANULI, not all original members of the mobile phone study were part of CANULI and therefore the original sample size became somewhat smaller.

Such a design has been used to follow adult people with a mobile phone contract (subscribers) for risk of disease compared with the rest of the Danish adult population; in other words, the whole Danish adult population was subdivided into subscribers and non-subscribers of mobile phones and followed up for incidence of cancer and other diseases.7 8 10 11The collection of mobile phone subscription records has been described in detail previously.7 In brief, 723 421 records for 1982-95 were obtained from the Danish network operators.

Exclusion criteria included corporate subscriptions (n=200 507) and others, as shown in figure 1.Entry into the CANULI cohort was at age 30 because younger people might have still been in the educational system.



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